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中藥分子藥理研究室

中醫分子藥理研究室
Molecular Pharmacology Laboratory of Chinese Medicine

 

主持人:李宗諺 副教授

    國立陽明大學 傳統醫藥學研究所博士

聯絡電話:03-2118800分機3537

電子郵件:joyamen@mail.cgu.edu.tw

實驗室位置:第二醫學大樓四樓

  研究主題

  • 肝臟學
  • 肥胖與脂肪肝
  • 脂肪肝與免疫耐受性
  • 抗氧化醫學
  • 中醫複方保肝機轉研究
  • 能量代謝與老化

研究室特性

  • 著重自發性學習與科研邏輯學推論
  • 以多元面向探究生理病理與醫藥的發展

 

 

研究室簡介

草本植物或其萃取物作為慢性肝損傷的使用在全世界各地有相當的經驗。我們以分子醫學標的作為研究策略來探討藥用植物對肝纖維化/脂肪性肝炎的調控機制,希望以科學實驗的研究結果發展傳統醫學或草藥在醫學應用的有力證據。以分子機制為探討的重點,找出傳統複方或植物化合物的作用。目前,我們實驗室已建立肝纖維化//脂肪性肝炎的實驗動物研究平台。藉此系統,我們從傳統複方茵陳蒿湯,證明其所具有抗氧化特色對肝纖維化/脂肪性肝炎的明顯作用機制。由於本實驗室主要是著重中草藥對肝纖維化與脂肪肝肝炎等疾病的分子機制探討及發展治療學的應用用。因此透過相關研究,希望能夠發展出對這些疾病的預防或治療的新藥或輔助醫學。加上現在已經建立的數種分析介面,例如對於肝臟組織代謝與分子層面調控的精確探討,都能讓我們的研究更具競爭優勢,並提供相關預防及治療的研究標的作用基礎。

There has been an increasing interest worldwide in the use of herbal medicines in chronic liver injury. Systematic studies on the effect of specific traditional Chinese medicinal herbs on hepatic fibrosis and steatohepatitis are designed to obtain evidence-based scientific knowledge on appropriate use of traditional medicinal decoction. In our lab we have established in vivo hepatic fibrosis/steatohepatitis system in mouse models to carry out both the mechanistic and therapeutic studies. We have successfully demonstrated the use of these systems for evaluating the antioxidant properties of Yin-Chen-Hao-Tang. Currently, studies are in progress to elucidate the detailed molecular mechanisms underlying the anti-inflammatory/immuno-modulating effects of herbal medicines or certain phytocompounds. Our goal is to develop therapeutic approaches to effectively prevent and treat these diseases.

 

論文發表

Lee TY. Chang HH. Chen JH. Hsueh ML. Kuo JJ. (2007) Herb medicine Yin-Chen-Hao-Tang ameliorates hepatic fibrosis in bile duct ligation rats. Journal of Ethnopharmacology. 109:318-324. (SCI)

Lee TY. Chang HH. Wu MY. Lin HC. (2007) Yin-Chen-Hao-Tang ameliorates obstruction-induced hepatic apoptosis in portal hypertension rats. Journal of Pharmacy & Pharmacology. 59:583-590. (SCI)

Lee TY. Chang HH. Kuo JJ. Shen JJ. (2009) Changes of hepatic proteome in bile duct ligated rats with hepatic fibrosis following treatment with Yin-Chen-Hao-Tang. International Journal of Molecular Medicine. 23: 477-484. (SCI)

Lee TY. Chen FY. Chang HH. Lin HC. (2009) The effect of capillarisin on glycochenodeoxycholic acid-induced apoptosis and heme oxygenase-1 in rat primary hepatocytes. Molecular Cellular Biochemistry 325: 53-59 (SCI)

Lee TY. Lee KC. Chen SY. Chang HH. (2009) 6-Gingerol inhibits ROS and iNOS through the suppression of PKC-alpha and NF-kB pathways in lipopolysaccharide-stimulated mouse macrophages. Biochemical and Biophysical Research Communications 382:134-139 (SCI)

Lee TY. Chang HH. (2010) Longdan Xiegan Tang has immunomodulatory effects on CD4+CD25+ T cells and attenuates pathological signs in MRL/lpr mice. International Journal of Molecular Medicine.25:677-685 (SCI)

Lee TY. Chang HH. Lo WC. Lin HC (2010) Alleviation of hepatic oxidative stress by Chinese herbal medicine Yin-Chen-Hao-Tang in obese mice with steatosis. International Journal of Molecular Medicine.25:837-844 (SCI)

Lee TY. Lee KC.Chang HH. (2010) Modulation of the cannabinoid receptors by andrographolide attenuates hepatic apoptosis following bile duct ligation in rats with fibrosis. Apoptosis 15:904-914 (SCI)

Lee KC. Chang HH. Lee TY. (2011) Andrographolide acts as an anti-inflammatory agent in lps-stimulated raw264.7 macrophages by inhibiting stat3-mediated suppression of the NF-kB pathway. Journal of Ethnopharmacology. 135:678-684 (SCI Correspondence author)

研討會論文與得獎紀錄

  • 95.03. 28 (2006) Shanghai-Hong Kong International Liver Congress (Shanghai, Best Poster Award)
  • 95.05.28第九屆工程科技與中西醫學應用研討會(Taichung, 優等獎)
  • 96.2.11-12基因體醫學國家型科技計畫95年度成果發表會(poster)
  • 96.07.26~30台灣生技月發表研究成果-台北(poster)
  • 96.12.02~0414屆國際東洋醫學會(poster, oral)
  • 97.04.23~27 43rd Annual Meeting of the European Association for the Study of the Liver (Italy, TOP 10% Award )
  • 97.06.12~15 (2008) Hong Kong-Shanghai International Liver Congress (Hong Kong, Best Oral Presentation)
  • 97.08.28~30 7th Meeting of the Consortium for Globalization of Chinese Medicine (Taipei, Best Poster Award)
  • 97.08.28 2008年長庚大學五校健康維護發展趨勢論壇(poster, 績優獎)
  • 97.10.30 九十七年度生物科技研發成果聯合發表會(oral)
  • 98. 04.16 2nd Taiwan-France Workshop on Herbal Medicine (Taipei, Invited Speaker)
  • 98.04.22~26 44rd Annual Meeting of the European Association for the Study of the Liver (Danmark, TOP 10% Award )
  • 98.07.24 台北生技展學研研發平台交流成果發表會 (oral)
  • 98.10.14-17 12th International Symposium on Molecular Medicine (Greece, Invited Speaker)
  • 99.04.15-18 45th European Association for the Study of the Liver (EASL)  (Austria, Young Investigator Registration Bursary)
  • 99. 05. 27-30 Interventional Hepatology Conference (Spain, Invited Speaker)
  • 99.06.04 財團法人醫藥品查驗中心 (Taipei, Invited Speaker)
  • 99.08  9th Meeting of the Consortium for Globalization of Chinese Medicine (Hong Kong Best Poster Award)
  • 100.04.01-05 46th European Association for the Study of the Liver (EASL)  (Germany, Young Investigator Registration Bursary)
  • 100. 06.06-08 Conference of “Novel Approaches of Bioavailability & Bioequivalence Studies”. (USA, Invited Speaker)
  • 100.12.01-04 The International Symposium on Ocular Pharmacology and Therapeutics “ ISOPT 2011”. (Vienna, Austria, Invited Speaker)

 

期刊論文編審

  • Liver International
  • Cytokine
  • Journal of Pharmacy and Pharmacology
  • Journal of Medicinal Food
  • Chinese Medicine
  • Method and Findings in Experimental and Clinical Pharmacology
  • British Journal of Pharmacology
  • Journal of Chinese Integrative Medicine
  • Hepatology International
  • Journal of Medicinal Food.
  • European Journal of Gastroenterology & Hepatology 
  • BMC Gastroenterology
  • PLos

 

 

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